selective (o)estrogen receptor modulator

= SERM
a drug that has oestrogen-like activity in some tissues and an anti-oestrogenic effect in others, depending on the manner of its binding with the oestrogen receptors. Tamoxifen was the first SERM to be introduced. Because of its activity as an anti-oestrogen it is used in the treatment of breast cancer, but its oestrogenic activity may cause side-effects. Raloxifene is used in the treatment of osteoporosis for its oestrogenic effects on bone density.

The new mediacal dictionary. 2014.

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  • Selective estrogen receptor modulator — Selective Estrogen Receptor Modulators (SERMs) are a class of medication that acts on the estrogen receptor.cite journal |author=Riggs BL, Hartmann LC|title=Selective estrogen receptor modulators mechanisms of action and application to clinical… …   Wikipedia

  • selective estrogen receptor modulator — n any of a class of drugs (as raloxifene or tamoxifen) that bind with estrogen receptors and act as estrogen agonists in some tissues and estrogen antagonists in other tissues abbr. SERM * * * (SERM) an agent that activates some estrogen… …   Medical dictionary

  • Selective Estrogen-Receptor Modulator (SERM) — A "designer estrogen" which possesses some, but not all, of the actions of estrogen. For example, raloxifene (trade name EVISTA) is classified as a SERM because it prevents bone loss (like estrogen) and lowers serum cholesterol (like… …   Medical dictionary

  • selective estrogen receptor modulator — SERM. A drug that acts like estrogen on some tissues but blocks the effect of estrogen on other tissues. Tamoxifen and raloxifene are SERMs. Also called SERM …   English dictionary of cancer terms

  • Selective androgen receptor modulator — Selective androgen receptor modulators or SARMs are a novel class of androgen receptor ligands. (The name follows the terminology currently used for similar molecules targeting the estrogen receptor, selective estrogen receptor modulators, such… …   Wikipedia

  • Selective progesterone receptor modulator — A selective progesterone receptor modulator (SPRM) is an agent that acts on the progesterone receptor. A characteristic that distinguishes such substances from receptor full agonists (such as progesterone) and full antagonists (such as RU 486) is …   Wikipedia

  • Estrogen receptor beta — See also: Estrogen receptor Estrogen receptor 2 (ER beta) PDB rendering based on 1hj1 …   Wikipedia

  • Estrogen-related receptor gamma — PDB rendering based on 1kv6 …   Wikipedia

  • Selective glucocorticoid receptor agonist — DIGRA redirects here. For the Digital Games Research Association, see DiGRA. Mapracorat, one of the furthest developed SEGRAs[1] A selective glucocorticoid receptor agonist (SEGRA), sometimes called a dissociated glucocorticoid receptor …   Wikipedia

  • modulator — That which regulates or adjusts. selective estrogen receptor m. (SERM) pharmaceutical agent with selective estrogen receptor affinity; current preparations have a primary effect on bone and …   Medical dictionary

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